Detailed GPO ?

Hello,

A little history:

We have an active GPO on the domain setting a specific home page (User config/Windows settings/Internet Explorer Maint/URLs/Important URLs) . The need arises to set up a different home page for specific users in dedicated OU, I set up the GPO in the same manner as the domain GPO which didn't make a change, domain GPO kept on overriding the OU GPO, I made changes to the OU GPO set up and went in the direction (User Config/Admin Templates/Windows Components/IE/Disable changing home page settings    "enabled this setting with listing the home page"), worked perfectly.

Does the set up have to differ in this type of a case, if so why? Ideally we would like to have the GPO's set up in the same manner, is that possible?

Thank you!