GPO won't apply to some OU's

I have 3 2008 R2 DC's using Group policys on multiple OU's. I found GPO's are not applying to Windows 7 clients in some of my OU's. If I move the computer to another OU policies are applied if I move it back they do not. I have created new OU's to test with and policies do not apply. Gpresults show the Default domain and a User Settings policy applied but the rest of inherited and linked policies do not. Very strange since this does not appear to be a client issue. I am on a very fast network and these GPO's have been in place for a long time.